Tine Casneuf

Postdoc (Group member from 2003 until 2007) + 32 (0) 9 33 13 692 VIB / Ghent University Bioinformatics & Systems Biology Technologiepark 927 B-9052 Gent BELGIUM

Research

It has been generally accepted that gene duplication increases the amount of genetic material as a necessary source for the origin of evolutionary novelties. Complete genomic analyses of different organisms now show that a major fraction of their genomes indeed consists of paralogous genes that arose through large-scale gene or entire genome duplication events. However, it is still unclear why so many duplicated genes are retained in genomes. Furthermore, also the (general) fate of initially redundant genes on a genome-wide scale is still unclear. Through large-scale analysis of functional data, I will study the role of genetic redundancy on the evolution of gene function in Arabidopsis thaliana.

Papers

(7) Vermeirssen, V., Joshi, A., Michoel, T., Bonnet, E., Casneuf, T., Van de Peer, Y. (2009) Transcription regulatory networks in Caenorhabditis elegans inferred through reverse-engineering of gene expression profiles constitute biological hypotheses for metazoan development. Molecular BioSystems 5(12):1817-30.

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(6) Vandepoele, K., Quimbaya, M., Casneuf, T., De Veylder, L., Van de Peer, Y. (2009) Unravelling transcriptional control in Arabidopsis using cis-regulatory elements and coexpression networks. Plant Physiol. 150(2):535-46.

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(5) Naouar, N., Vandepoele, K., Lammens, T., Casneuf, T., Zeller, G., van, Hummelen, Weigel, D., Rätsch, G., Inzé, D., Kuiper, M., De Veylder, L., Vuylsteke, M. (2008) Quantitative RNA expression analysis with Affymetrix Tiling 1.0R arrays identifies new E2F target genes. Plant J. 57(1):184-94.

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(4) Casneuf, T., Van de Peer, Y., Huber, H. (2007) In situ Analysis of Cross-Hybridisation on Microarrays and the Inference of Expression Correlation. BMC Bioinformatics 8:461.

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(3) Vandepoele, K., Casneuf, T., Van de Peer, Y. (2006) Identification of novel regulatory modules in dicot plants using expression data and comparative genomics. Genome Biol. 7(11):R103.

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(2) Casneuf, T., De Bodt, S., Raes, J., Maere, S., Van de Peer, Y. (2006) Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana. Genome Biol. 7(2):R13.

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(1) * Maere, S., * De Bodt, S., Raes, J., Casneuf, T., Van Montagu, M., Kuiper, M., Van de Peer, Y. (2005) Modeling gene and genome duplications in eukaryotes. Proc. Natl. Acad. Sci. USA 102(15):5454-9. *contributed equally

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